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Article

Prognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysis.

Scientific reports - 1 Sept 2014

Pang Bo, Cheng Shi, Sun Shi-Peng, An Cheng, Liu Zhi-Yuan, Feng Xue, Liu Gui-Jian

Abstract excerpt

The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs), including estrogen receptor (ER) and progesterone receptor (PR) play pivotal roles in BCa. In this study, we evaluated the association between PIK3CA mutations and ER/PR expression and the prognostic role of PIK3CA mutations in BCa patients, and in...

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Identifiers

PMID: 25176561
DOI: 10.1038/srep06255
PMCID: PMC4150110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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