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Article

A preclinical mouse model of glioma with an alternative mechanism of telomere maintenance (ALT).

International journal of cancer - 1 Apr 2015

Jeitany Maya, Pineda Jose Ramon, Liu Qingyuan, Porreca Rosa Maria, Hoffschir Françoise, Desmaze Chantal, Silvestre David C, Mailliet Patrick, Junier Marie-Pierre, Londoño-Vallejo Arturo, Ségal-Bendirdjian Evelyne, Chneiweiss Hervé, Boussin François D

Abstract excerpt

Glioblastoma multiforme is the most aggressive primary tumor of the central nervous system. Glioma stem cells (GSCs), a small population of tumor cells with stem-like properties, are supposedly responsible for glioblastoma multiforme relapse after current therapies. In approximately thirty percent of glioblastoma multiforme tumors, telomeres are not maintained by telomerase but through an alternative mechanism,...

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Identifiers

PMID: 25175359
DOI: 10.1002/ijc.29171
PMCID: PMC4303977

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Source receipt: pubmed, retrieved 7 Sept 2026.

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