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Article

Alternative Lengthening of Telomeres in Human Glioma Stem Cells

14 Jan 2011

Abstract excerpt

Cancer stem cells are increasingly recognized as major therapeutic targets. We report here the isolation of glioma stem cells (GSCs) maintaining telomere length through a telomerase-independent mechanism known as alternative lengthening of telomeres (ALTs). TG20 cells were isolated from a glioblastoma multiforme, which had the ALT phenotype. They have no detectable telomerase activity and extremely long and...

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PMID: 21425407
DOI: 10.1002/stem.600

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