Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461

10 Apr 2018

Abstract excerpt

BACKGROUND: Glioma is a heterogeneous, invasive primary brain tumor with a wide range of patient survival and a lack of reliable prognostic biomarkers. Human telomerase reverse transcriptase (hTERT) has been reported in the presence of multiple transcripts in various tumor systems. The biological function and precise regulatory mechanisms of hTERT transcripts remain uncertain. METHODS: Alternative splicing of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nuclear Structure and Function
Share to PARP inhibition in cancer therapy
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29631594
DOI: 10.1186/s13046-018-0749-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461PMID 29631594Read ↗

The Biological and Clinical Role of the Telomerase Reverse Transcriptase Gene in Glioblastoma: A Potential Therapeutic Target?Semantic proximity Read ↗

When the Ends Are Really the Beginnings: Targeting Telomerase for Treatment of GBM.Semantic proximity Read ↗

Telomerase as a therapeutic target in glioblastoma.Semantic proximity Read ↗

Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in GliomasSemantic proximity Read ↗

Alternative Splicing of hTERT Pre-mRNA: A Potential Strategy for the Regulation of Telomerase Activity.Semantic proximity Read ↗

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological ProcessesSemantic proximity Read ↗

Regulation of Telomerase Activity by Alternate Splicing of Human Telomerase Reverse Transcriptase mRNA in a Subset of NeuroblastomasSemantic proximity Read ↗

Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?Semantic proximity Read ↗

A novel variant of telomerase reverse transcriptase (TERT) associated with risk of glioma in a Korean population.Semantic proximity Read ↗

Telomerase Activity in Human GliomasSemantic proximity Read ↗

Correlation between IDH, ATRX, and TERT promoter mutations in glioma.Semantic proximity Read ↗

In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.