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Article

Dual Lentiviral Transduction To Generate Mutant Neural Stem Cells For Glioma Research.

Journal of visualized experiments : JoVE - 10 Jul 2026

Adhikari Manish, Gerhard Emma, Martin Gemma, Brossier Nicole M

Abstract excerpt

Gliomas are the most prevalent primary brain tumors in adults, and murine modeling suggests that they may arise from oncogenic mutations in NSCs or early differentiating progenitors. Orthotopic transplantation models derived from mutant NSCs thus have the potential to yield valuable preclinical information about glioma pathogenesis, outcomes, and treatment response. These models require the introduction of an...

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PMID: 42507622
DOI: 10.3791/70692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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