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Article

Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.

Cancer research - 15 Sept 2014

DeFilippis Rosa Anna, Fordyce Colleen, Patten Kelley, Chang Hang, Zhao Jianxin, Fontenay Gerald V, Kerlikowske Karla, Parvin Bahram, Tlsty Thea D

Abstract excerpt

Telomere malfunction and other types of DNA damage induce an activin A-dependent stress response in mortal nontumorigenic human mammary epithelial cells that subsequently induces desmoplastic-like phenotypes in neighboring fibroblasts. Some characteristics of this fibroblast/stromal response, such as reduced adipocytes and increased extracellular matrix content, are observed not only in tumor tissues but also in...

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Identifiers

PMID: 25172842
DOI: 10.1158/0008-5472.CAN-13-3390
PMCID: PMC4335659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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