Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor Tissues

10 Jul 2012

Abstract excerpt

UNLABELLED: Although high mammographic density is considered one of the strongest risk factors for invasive breast cancer, the genes involved in modulating this clinical feature are unknown. Tissues of high mammographic density share key histologic features with stromal components within malignant lesions of tumor tissues, specifically low adipocyte and high extracellular matrix (ECM) content. We show that CD36,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Lesions and Carcinomas
Share to Cancer, Lipids, and Metabolism
Share to Cancer Risks and Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22777768
DOI: 10.1158/2159-8290.cd-12-0107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD36 Repression Activates a Multicellular Stromal Program Shared by High Mammographic Density and Tumor TissuesPMID 22777768Read ↗

Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.Semantic proximity Read ↗

High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium.Semantic proximity Read ↗

High mammographic density in women is associated with protumor inflammation.Semantic proximity Read ↗

Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast CancerSemantic proximity Read ↗

Mammographic breast density as an intermediate phenotype for breast cancer.Semantic proximity Read ↗

Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.Semantic proximity Read ↗

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer preventionSemantic proximity Read ↗

Mechanical phenotype is important for stromal aromatase expression.Semantic proximity Read ↗

Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descentSemantic proximity Read ↗

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci.Semantic proximity Read ↗

Influence of genetic ancestry on breast stromal cells provides biologic basis for increased incidence of metaplastic breast cancer in women of African descentSemantic proximity Read ↗

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.