Article
Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci.
Breast cancer research : BCR - 12 Apr 2022
Chen Hongjie, Fan Shaoqi, Stone Jennifer, Thompson Deborah J, Douglas Julie, Li Shuai, Scott Christopher, Bolla Manjeet K, Wang Qin, Dennis Joe, Michailidou Kyriaki, Li Christopher, Peters Ulrike, Hopper John L, Southey Melissa C, Nguyen-Dumont Tu, Nguyen Tuong L, Fasching Peter A, Behrens Annika, Cadby Gemma, Murphy Rachel A, Aronson Kristan, Howell Anthony, Astley Susan, Couch Fergus, Olson Janet, Milne Roger L, Giles Graham G, Haiman Christopher A, Maskarinec Gertraud, Winham Stacey, John Esther M, Kurian Allison, Eliassen Heather, Andrulis Irene, Evans D Gareth, Newman William G, Hall Per, Czene Kamila, Swerdlow Anthony, Jones Michael, Pollan Marina, Fernandez-Navarro Pablo, McConnell Daniel S, Kristensen Vessela N, Rothstein Joseph H, Wang Pei, Habel Laurel A, Sieh Weiva, Dunning Alison M, Pharoah Paul D P, Easton Douglas F, Gierach Gretchen L, Tamimi Rulla M, Vachon Celine M, Lindström Sara
Abstract excerpt
BACKGROUND: Mammographic density (MD) phenotypes, including percent density (PMD), area of dense tissue (DA), and area of non-dense tissue (NDA), are associated with breast cancer risk. Twin studies suggest that MD phenotypes are highly heritable. However, only a small proportion of their variance is explained by identified genetic variants. METHODS: We conducted a genome-wide association study, as well as a...
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