Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes

7 Dec 2012

Abstract excerpt

INTRODUCTION: Tumors are characterized by alterations in the epithelial and stromal compartments, which both contribute to tumor promotion. However, where, when, and how the tumor stroma develops is still poorly understood. We previously demonstrated that DNA damage or telomere malfunction induces an activin A-dependent epithelial stress response that activates cell-intrinsic and cell-extrinsic consequences in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Telomeres, Telomerase, and Senescence
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23216814
DOI: 10.1186/bcr3368

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypesPMID 23216814Read ↗

Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.Semantic proximity Read ↗

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesisSemantic proximity Read ↗

Role of oxidative stress and the microenvironment in breast cancer development and progression.Semantic proximity Read ↗

DNA Damage Drives an Activin A–Dependent Induction of Cyclooxygenase-2 in Premalignant Cells and LesionsSemantic proximity Read ↗

Know thy neighbor: stromal cells can contribute oncogenic signals.Semantic proximity Read ↗

A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated MechanotransductionSemantic proximity Read ↗

Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistanceSemantic proximity Read ↗

Dualism of FGF and TGF-β Signaling in Heterogeneous Cancer-Associated Fibroblast Activation with ETV1 as a Critical DeterminantSemantic proximity Read ↗

Cancer-Associated Fibroblasts and Their Putative Role in Potentiating the Initiation and Development of Epithelial Ovarian CancerSemantic proximity Read ↗

Stromagenesis: the changing face of fibroblastic microenvironments during tumor progression.Semantic proximity Read ↗

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal TransitionSemantic proximity Read ↗

Paracrine Signals from the Tumor Microenvironment Modulate Stem-Cell Collagen Interaction, Remodeling and Reprogramming Toward a Cancer-Associated PhenotypeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.