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Article

Rearrangement of upstream sequences of the hTERT gene during cellular immortalization.

Genes, chromosomes & cancer - 1 Nov 2009

Zhao Yuanjun, Wang Shuwen, Popova Evgenya Y, Grigoryev Sergei A, Zhu Jiyue

Abstract excerpt

Telomerase expression, resulting from transcriptional activation of the hTERT gene, allows cells to acquire indefinite proliferative potential during cellular immortalization and tumorigenesis. However, mechanisms of hTERT gene activation in many immortal cell lines and cancer cells are poorly understood. Here, we report our studies on hTERT activation using genetically related pairs of telomerase-negative...

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Identifiers

PMID: 19672873
DOI: 10.1002/gcc.20698
PMCID: PMC2889911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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