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Article

Epidermal growth factor activates telomerase activity by direct binding of Ets-2 to hTERT promoter in lung cancer cells.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2015

Hsu Chung-Ping, Lee Li-Wen, Tang Sheau-Chung, Hsin I-Lun, Lin Yu-Wen, Ko Jiunn-Liang

Abstract excerpt

Growth signals are directly or indirectly involved in telomerase regulation. In this study, we investigated molecular mechanisms of the effect of EGF (epidermal growth factor) on regulating hTERT (human telomerase reverse transcriptase) expression. To elucidate specific transcription factors involved in EGF-stimulated hTERT transcription in A549 and H1299 lung cancer cells, transcription factors drives hTERT...

Read the complete abstract on PubMed

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Share to Cell Line, Tumor
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Gene Expression Regulation, Enzymologic

Share to Lung Neoplasms

Share to Proto-Oncogene Proteins c-myc

Share to Telomerase

Share to Transcription, Genetic

Source

Identifiers

PMID: 25680408
DOI: 10.1007/s13277-015-3204-x

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Epidermal growth factor activates telomerase activity by direct binding of Ets-2 to hTERT promoter in lung cancer cells.PMID 25680408Read ↗

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