Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents.

Platelets - 1 Jan 2015

Janse van Rensburg Walter J, Badenhorst Philip N, Roodt Jan P

Abstract excerpt

An effective and safe anti-platelet drug is central to the management of patients with acute coronary syndrome (ACS). Glycoprotein VI (GPVI) is currently regarded as a potential target for novel anti-platelet agents due to its collagen-binding potential. Development of anti-thrombotics is associated with testing in animals. We have previously successfully evaluated anti-platelet drugs in the Cape Chacma baboon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Antibodies, Monoclonal
Share to Collagen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Evaluation, Preclinical

Share to Models, Animal

Share to Platelet Aggregation

Share to Platelet Aggregation Inhibitors

Share to Platelet Membrane Glycoproteins

Source

Identifiers

PMID: 25165849
DOI: 10.3109/09537104.2014.952224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents.PMID 25165849Read ↗

Engineered human soluble calcium-activated nucleotidase inhibits coagulation in vitro and thrombosis in vivo.Semantic proximity Read ↗

The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletionSemantic proximity Read ↗

Targeting platelet GPVI or GPIIb/IIIa only minimally affect acute inflammation and cardiac repair in experimental permanent myocardial infarctionSemantic proximity Read ↗

Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitorsSemantic proximity Read ↗

A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder.Semantic proximity Read ↗

Targeting Thymidine Phosphorylase with Tipiracil Hydrochloride is a Safe and Effective Antithrombotic TherapySemantic proximity Read ↗

The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression.Semantic proximity Read ↗

Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations.Semantic proximity Read ↗

An αIIb β3 antagonist prevents thrombosis without causing Fc receptor γ-chain IIa-mediated thrombocytopenia.Semantic proximity Read ↗

Taipan snake venom time for antiphospholipid syndrome solves a 20-year diagnostic challenge.Semantic proximity Read ↗

Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafishSemantic proximity Read ↗

Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.