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Article

Crystal structure and its bearing towards an understanding of key biological functions of EpCAM.

Nature communications - 28 Aug 2014

Pavšič Miha, Gunčar Gregor, Djinović-Carugo Kristina, Lenarčič Brigita

Abstract excerpt

EpCAM (epithelial cell adhesion molecule), a stem and carcinoma cell marker, is a cell surface protein involved in homotypic cell-cell adhesion via intercellular oligomerization and proliferative signalling via proteolytic cleavage. Despite its use as a diagnostic marker and being a drug target, structural details of this conserved vertebrate-exclusive protein remain unknown. Here we present the crystal structure...

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Source

Identifiers

PMID: 25163760
DOI: 10.1038/ncomms5764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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