Article
Genetic dissection of drug effects in clinical practice: CLOCK gene and clozapine-induced diurnal sleepiness.
Neuroscience letters - 2 Sept 2004
Lattuada Enrico, Cavallaro Roberto, Benedetti Francesco, Cocchi Federica, Lorenzi Cristina, Smeraldi Enrico
Abstract excerpt
Psychotic patients treated with clozapine often experience persistent daytime sleepiness. This is a frequent side effect of clozapine that may reduce patient compliance. We hypothesized that clozapine might interfere with the circadian rhythms regulated by the biological clock. In 171 patients with major psychosis, we investigated the association between hypersomnolence during clozapine therapy and a CLOCK gene...
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