Article
No evidence for association of alpha 1a adrenoceptor gene polymorphism and clozapine-induced urinary incontinence.
Neuropsychobiology - 1 Jan 2000
Hsu J W, Wang Y C, Lin C C, Bai Y M, Chen J Y, Chiu H J, Tsai S J, Hong C J
Abstract excerpt
Clozapine is an effective atypical antipsychotic that has high affinity for many neurotransmitter receptors. Among the adverse effects of clozapine, urinary incontinence is commonly found and is suggested to be caused by alpha-adrenergic blockade. We tested the hypothesis that clozapine-induced urinary incontinence is related to a genetic variant of the alpha(1a)-adrenoceptor. We also tested whether the...
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