Article
Apolipoprotein E genotype and the diagnostic accuracy of cerebrospinal fluid biomarkers for Alzheimer disease.
JAMA psychiatry - 1 Oct 2014
Lautner Ronald, Palmqvist Sebastian, Mattsson Niklas, Andreasson Ulf, Wallin Anders, Pålsson Erik, Jakobsson Joel, Herukka Sanna-Kaisa, Owenius Rikard, Olsson Bob, Hampel Harald, Rujescu Dan, Ewers Michael, Landén Mikael, Minthon Lennart, Blennow Kaj, Zetterberg Henrik, Hansson Oskar
Abstract excerpt
IMPORTANCE: Several studies suggest that the apolipoprotein E (APOE) ε4 allele modulates cerebrospinal fluid (CSF) levels of β-amyloid 42 (Aβ42). Whether this effect is secondary to the association of the APOE ε4 allele with cortical Aβ deposition or whether APOE ε4 directly influences CSF levels of Aβ42 independently of Aβ pathology remains unknown. OBJECTIVE: To evaluate whether the APOE genotype affects the...
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