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Article

The screening of Alzheimer's patients with CSF biomarkers, modulates the distribution of APOE genotype: impact on clinical trials.

Journal of neurology - 1 Jun 2014

Dumurgier Julien, Laplanche Jean-Louis, Mouton-Liger Francois, Lapalus Pauline, Indart Sandrine, Prévot Magali, Peoc'h Katell, Hugon Jacques, Paquet Claire

Abstract excerpt

Polymorphism of the apolipoprotein E gene (APOE) plays a role in the level of neuropathological lesions and in drug response in Alzheimer's disease (AD). The aim of this study was to investigate whether the selection of AD patients based on cerebrospinal fluid (CSF) biomarkers assessment may be biased by their APOE distribution. We studied the relationships between APOE genotype and CSF biomarkers levels in a...

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Source

Identifiers

PMID: 24728335
DOI: 10.1007/s00415-014-7335-6

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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