Structural and Molecular Interactions of CCR5 Inhibitors with CCR5

Abstract excerpt

We have characterized the structural and molecular interactions of CC-chemokine receptor 5 (CCR5) with three CCR5 inhibitors active against R5 human immunodeficiency virus type 1 (HIV-1) including the potent in vitro and in vivo CCR5 inhibitor aplaviroc (AVC). The data obtained with saturation binding assays and structural analyses delineated the key interactions responsible for the binding of CCR5 inhibitors...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HIV Research and Treatment
• Share to Immune Cell Function and Interaction
• Share to Monoclonal and Polyclonal Antibodies Research