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Article

N-acetyltransferase 1 polymorphism increases cotinine levels in Caucasian children exposed to secondhand smoke: the CCAAPS birth cohort.

The pharmacogenomics journal - 1 Apr 2015

LeMasters G K, Khurana Hershey G K, Sivaprasad U, Martin L J, Pilipenko V, Ericksen M B, Burkle J W, Lindsey M A, Bernstein D I, Lockey J E, Gareri J, Lubetsky A, Koren G, Biagini Myers J M

Abstract excerpt

Cotinine is a proxy for secondhand smoke (SHS) exposure. Genetic variation along nicotine and cotinine metabolic pathways may alter the internal cotinine dose, leading to misinterpretations of exposure-health outcome associations. Caucasian children with available SHS exposure and hair cotinine data were genotyped for metabolism-related genes. SHS-exposed children had 2.4-fold higher hair cotinine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25156213
DOI: 10.1038/tpj.2014.44
PMCID: PMC4342329

Genes

NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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