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Article

Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state

28 Aug 2008

Abstract excerpt

Renewal of stem cells differs from cancer cell growth in self-controlled cell division. The mir-302 microRNA (miRNA) family (mir-302s) is expressed most abundantly in slow-growing human embryonic stem (ES) cells, and quickly decreases after cell differentiation and proliferation. Therefore, mir-302s was investigated as one of the key factors essential for maintenance of ES cell renewal and pluripotency in this...

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PMID: 18755840
DOI: 10.1261/rna.1162708

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