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Article

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate

3 Oct 2019

Abstract excerpt

Embryonal carcinomas (ECs) and seminomas are testicular germ cell tumors. ECs display expression of SOX2, while seminomas display expression of SOX17. In somatic differentiation, SOX17 drives endodermal cell fate. However, seminomas lack expression of endoderm markers, but show features of pluripotency. Here, we use chromatin immunoprecipitation sequencing to report and compare the binding pattern of SOX17 in...

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PMID: 31583686
DOI: 10.1002/ijc.32714

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