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Article

SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer

1 Apr 2019

Abstract excerpt

Transcriptional and epigenetic embryonic programs can be reactivated in cancer cells. As result, a specific subset of undifferentiated cells with stem-cells properties emerges and drives tumorigenesis. Recent findings have shown that ectoderm- and endoderm-derived tissues continue expressing stem-cells related transcription factors of the SOX-family of proteins such as SOX2 and SOX9 which have been implicated in...

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PMID: 31057614
DOI: 10.1155/2019/6754040

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