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Article

Impact of ABCB1 single nucleotide polymorphisms 1236C>T and 2677G>T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype.

British journal of haematology - 1 Dec 2014

Jakobsen Falk Ingrid, Fyrberg Anna, Paul Esbjörn, Nahi Hareth, Hermanson Monica, Rosenquist Richard, Höglund Martin, Palmqvist Lars, Stockelberg Dick, Wei Yuan, Gréen Henrik, Lotfi Kourosh

Abstract excerpt

Drug resistance is a clinically relevant problem in the treatment of acute myeloid leukaemia (AML). We have previously reported a relationship between single nucleotide polymorphisms (SNPs) of ABCB1, encoding the multi-drug transporter P-glycoprotein, and overall survival (OS) in normal karyotype (NK)-AML. Here we extended this material, enabling subgroup analysis based on FLT3 and NPM1 status, to further...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25155901
DOI: 10.1111/bjh.13097

Genes

FLT3
ABCB1
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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