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Article

Decreased survival in normal karyotype AML with single-nucleotide polymorphisms in genes encoding the AraC metabolizing enzymes cytidine deaminase and 5'-nucleotidase.

American journal of hematology - 1 Dec 2013

Falk Ingrid Jakobsen, Fyrberg Anna, Paul Esbjörn, Nahi Hareth, Hermanson Monica, Rosenquist Richard, Höglund Martin, Palmqvist Lars, Stockelberg Dick, Wei Yuan, Gréen Henrik, Lotfi Kourosh

Abstract excerpt

De novo acute myeloid leukemia with normal karyotype (NK-AML) comprises a large group of patients with no common cytogenetic alterations and with a large variation in treatment response. Single-nucleotide polymorphisms (SNPs) in genes related to the metabolism of the nucleoside analogue AraC, the...

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Share to 5'-Nucleotidase
Share to Antimetabolites, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Inactivation, Metabolic

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Source

Identifiers

PMID: 23873772
DOI: 10.1002/ajh.23549

Genes

CDA
FLT3
DCK
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23873772-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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