Impact of ABC single nucleotide polymorphisms upon the efficacy and toxicity of induction chemotherapy in acute myeloid leukemia.

doi:10.1080/10428194.2016.1231405

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Article

Impact of ABC single nucleotide polymorphisms upon the efficacy and toxicity of induction chemotherapy in acute myeloid leukemia.

Leukemia & lymphoma - 1 May 2017

Megías-Vericat Juan Eduardo, Montesinos Pau, Herrero María José, Moscardó Federico, Bosó Virginia, Rojas Luis, Martínez-Cuadrón David, Hervás David, Boluda Blanca, García-Robles Ana, Rodríguez-Veiga Rebeca, Martín-Cerezuela María, Cervera José, Sendra Luis, Sanz Jaime, Miguel Antonio, Lorenzo Ignacio, Poveda José Luis, Sanz Miguel Ángel, Aliño Salvador F

Abstract excerpt

Anthracycline uptake could be affected by efflux pumps of the ABC family. The influence of 7 SNPs of ABC genes was evaluated in 225 adult de novo acute myeloid leukemia (AML) patients. After multivariate logistic regression there were no significant differences in complete remission, though induction death was associated to ABCB1 triple variant haplotype (p = .020). The ABCB1 triple variant haplotype was related...

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Identifiers

PMID: 27701910
DOI: 10.1080/10428194.2016.1231405

Genes

ABCB1
ABCC1
ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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