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Article

Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.

PloS one - 1 Jan 2018

Murcia Oscar, Juárez Míriam, Rodríguez-Soler María, Hernández-Illán Eva, Giner-Calabuig Mar, Alustiza Miren, Egoavil Cecilia, Castillejo Adela, Alenda Cristina, Barberá Víctor, Mangas-Sanjuan Carolina, Yuste Ana, Bujanda Luís, Clofent Joan, Andreu Montserrat, Castells Antoni, Llor Xavier, Zapater Pedro, Jover Rodrigo

Abstract excerpt

OBJECTIVE: The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype's response to chemotherapy. DESIGN: This retrospective observational study included a population-based cohort of 878 CRC patients. We classified tumours into five different...

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Identifiers

PMID: 30188916
DOI: 10.1371/journal.pone.0203051
PMCID: PMC6126803

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Source receipt: pubmed, retrieved 7 Sept 2026.

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