Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.

doi:10.1371/journal.pone.0203051

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.

PloS one - 1 Jan 2018

Murcia Oscar, Juárez Míriam, Rodríguez-Soler María, Hernández-Illán Eva, Giner-Calabuig Mar, Alustiza Miren, Egoavil Cecilia, Castillejo Adela, Alenda Cristina, Barberá Víctor, Mangas-Sanjuan Carolina, Yuste Ana, Bujanda Luís, Clofent Joan, Andreu Montserrat, Castells Antoni, Llor Xavier, Zapater Pedro, Jover Rodrigo

Abstract excerpt

OBJECTIVE: The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype's response to chemotherapy. DESIGN: This retrospective obser...

Topics

Adult
Aged
Antimetabolites, Antineoplastic
Biomarkers, Tumor
Colorectal Neoplasms
CpG Islands
DNA Methylation
Female
Fluorouracil
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Microsatellite Instability

Middle Aged

Mutation

Neoplasm Staging

Prognosis

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 30188916
DOI: 10.1371/journal.pone.0203051
PMCID: PMC6126803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-30188916-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.