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Microsatellite Instability, Prognosis and Drug Sensitivity of Stage II and III Colorectal Cancer: More Complexity to the Puzzle

19 May 2011

Abstract excerpt

Microsatellite instability (MSI), the abnormal shortening or lengthening of DNA by 1–6 repeating base pair units, is the result of inactivation of the DNA mismatch repair (MMR) system and characterizes approximately 15% of colorectal cancers (CRCs) ( 1 ). Two distinct mechanisms can cause MMR deficiency (dMMR): 1) germline mutational inactivation of the MMR genes, present in CRC patients with Lynch Syndrome and...

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PMID: 21597023
DOI: 10.1093/jnci/djr170

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