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Article

Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication.

Journal of the National Cancer Institute - 7 Aug 2013

Lochhead Paul, Kuchiba Aya, Imamura Yu, Liao Xiaoyun, Yamauchi Mai, Nishihara Reiko, Qian Zhi Rong, Morikawa Teppei, Shen Jeanne, Meyerhardt Jeffrey A, Fuchs Charles S, Ogino Shuji

Abstract excerpt

BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through its relationship with high-level CpG island methylator phenotype (CIMP) and MLH1 promoter methylation. MSI and BRAF mutation analyses are routinely used for familial cancer risk assessment. To clarify clinical outcome associations of combined MSI/BRAF subgroups, we investigated survival in 1253 rectal and colon cancer...

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Source

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Identifiers

PMID: 23878352
DOI: 10.1093/jnci/djt173
PMCID: PMC3735463

Genes

BRAF
KRAS
MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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