Article
Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication.
Journal of the National Cancer Institute - 7 Aug 2013
Lochhead Paul, Kuchiba Aya, Imamura Yu, Liao Xiaoyun, Yamauchi Mai, Nishihara Reiko, Qian Zhi Rong, Morikawa Teppei, Shen Jeanne, Meyerhardt Jeffrey A, Fuchs Charles S, Ogino Shuji
Abstract excerpt
BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through its relationship with high-level CpG island methylator phenotype (CIMP) and MLH1 promoter methylation. MSI and BRAF mutation analyses are routinely used for familial cancer risk assessment. To clarify c...
Topics
- Adult
- Aged
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- DNA Mutational Analysis
- Female
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- Mutation
- Odds Ratio
- Phenotype
- Predictive Value of Tests