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Article

Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice.

eLife - 29 Oct 2013

Sun Liou Y, Spong Adam, Swindell William R, Fang Yimin, Hill Cristal, Huber Joshua A, Boehm Jacob D, Westbrook Reyhan, Salvatori Roberto, Bartke Andrzej

Abstract excerpt

We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress resistance, and insulin signaling. These mutant mice also have increased adiponectin levels and alterations in glucose...

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Source

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Identifiers

PMID: 24175087
DOI: 10.7554/eLife.01098
PMCID: PMC3810783

Genes

GHRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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