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Central Suppression of the GH/IGF Axis and Abrogation of Exercise-Related mTORC1/2 Activation in the Muscle of Phenotype-Selected Male Marathon Mice (DUhTP).

Cells - 4 Dec 2021

Brenmoehl Julia, Walz Christina, Caffier Caroline, Brosig Elli, Walz Michael, Ohde Daniela, Trakooljul Nares, Langhammer Martina, Ponsuksili Siriluck, Wimmers Klaus, Zettl Uwe K, Hoeflich Andreas

Abstract excerpt

The somatotropic axis is required for a number of biological processes, including growth, metabolism, and aging. Due to its central effects on growth and metabolism and with respect to its positive effects on muscle mass, regulation of the GH/IGF-system during endurance exercise is of particular interest. In order to study the control of gene expression and adaptation related to physical performance, we used a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34943926
DOI: 10.3390/cells10123418
PMCID: PMC8699648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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