Article
Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2003
Shimokawa Isao, Higami Yoshikazu, Tsuchiya Tomoshi, Otani Hiroshi, Komatsu Toshimitsu, Chiba Takuya, Yamaza Haruyoshi
Abstract excerpt
A reduced growth hormone (GH)-insulin-like growth factor (IGF)-1 axis is associated with an extension of lifespan in laboratory rodents. Several phenotypes of such animal models resemble those induced by caloric restriction (CR). Using a transgenic male Wistar rat model whose GH-IGF-1 axis was moderately suppressed by overexpression of the antisense GH transgene (tg), we elucidated a relationship between the...
Topics
- Adenoma
- Animals
- Animals, Genetically Modified
- Caloric Restriction
- Coronary Thrombosis
- Disease
- Growth Hormone
- Heterozygote
- Insulin-Like Growth Factor I
- Kidney Diseases
- Longevity
- Male
- Models, Biological