Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases.

Experimental & molecular medicine - 31 Dec 2001

Patel M S, Korotchkina L G

Abstract excerpt

This review summarizes the recent developments on the regulation of human pyruvate dehydrogenase complex (PDC) by site-specific phosphorylation by four kinases. Mutagenic analysis of the three phosphorylation sites of human pyruvate dehydrogenase (E1) showed the site-independent mechanism of phosphorylation as well as site-independent dephosphorylation of the three phosphorylation sites and the importance of each...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Isoenzymes

Share to Oxidation-Reduction

Share to Phosphotransferases

Share to Pyruvate Dehydrogenase Complex

Share to Pyruvate Dehydrogenase (Lipoamide)

Share to Substrate Specificity

Source

Identifiers

PMID: 11795479
DOI: 10.1038/emm.2001.32

Genes

PDC
PDK1
PDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases.PMID 11795479Read ↗

Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.Semantic proximity Read ↗

Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites.Semantic proximity Read ↗

The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress.Semantic proximity Read ↗

Characterization of the isozymes of pyruvate dehydrogenase phosphatase: implications for the regulation of pyruvate dehydrogenase activity.Semantic proximity Read ↗

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.Semantic proximity Read ↗

Multiple functions of pyruvate kinase M2 in various cell typesSemantic proximity Read ↗

Specificity determinants for the pyruvate dehydrogenase component reaction mapped with mutated and prosthetic group modified lipoyl domains.Semantic proximity Read ↗

Mitochondrial Protein Phosphorylation as a Regulatory Modality: Implications for Mitochondrial Dysfunction in Heart FailureSemantic proximity Read ↗

Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction.Semantic proximity Read ↗

Pyruvate dehydrogenase phosphatase deficiency: orphan disease or an under-diagnosed condition?Semantic proximity Read ↗

Site-directed mutagenesis as a tool for the study of the allosteric control of pyruvate kinase.Semantic proximity Read ↗

Structural insight into mechanisms for dynamic regulation of PKM2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.