Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathophysiology of manganese-associated neurotoxicity.

Neurotoxicology - 1 Aug 2012

Racette Brad A, Aschner Michael, Guilarte Tomas R, Dydak Ulrike, Criswell Susan R, Zheng Wei

Abstract excerpt

Manganese (Mn) is a well established neurotoxin associated with specific damage to the basal ganglia in humans. The phenotype associated with Mn neurotoxicity was first described in two workers with occupational exposure to Mn oxide (Couper, 1837). Although the description did not use modern clinical terminology, a parkinsonian illness characterized by slowness of movement (bradykinesia), masked facies, and gait...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Air Pollutants, Occupational
Share to Aspartic Acid
Share to gamma-Aminobutyric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Manganese

Share to Occupational Diseases

Share to Occupational Exposure

Share to Parkinson Disease, Secondary

Share to Positron-Emission Tomography

Source

Open in PubMed Open full text

Identifiers

PMID: 22202748
DOI: 10.1016/j.neuro.2011.12.010
PMCID: PMC3350837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathophysiology of manganese-associated neurotoxicity.PMID 22202748Read ↗

Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies.Semantic proximity Read ↗

Manganese Neurotoxicity: A Comprehensive Review of Pathophysiology and Inherited and Acquired DisordersSemantic proximity Read ↗

Manganese Overexposure: Unveiling its Neurotoxic Potential and Involvement in Pathogenesis of Parkinson's DiseaseSemantic proximity Read ↗

Dopamine controls the Sensitivity to Manganese induced Dopaminergic neurotoxicity in <i>Caenorhabditis elegans</i>Semantic proximity Read ↗

Biotin rescues manganese-induced Parkinson’s disease phenotypes and neurotoxicitySemantic proximity Read ↗

Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese.Semantic proximity Read ↗

Hereditary Disorders of Manganese Metabolism: Pathophysiology of Childhood-Onset Dystonia-Parkinsonism in SLC39A14 Mutation Carriers and Genetic Animal Models.Semantic proximity Read ↗

Are there common biochemical and molecular mechanisms controlling manganism and parkisonism.Semantic proximity Read ↗

Role of excretion in manganese homeostasis and neurotoxicity: a historical perspective.Semantic proximity Read ↗

Mitochondrially Transcribed dsRNA Mediates Manganese-induced NeuroinflammationSemantic proximity Read ↗

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.Semantic proximity Read ↗

Activity of the manganese efflux transporter SLC30A10 in dopaminergic but not GABAergic neurons protects against neurotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.