The candidate gene approach: have murine models informed the study of human SLE?

Abstract excerpt

Genome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin-pointing the susceptibility alleles in candidate genes within these linkage regions is challenging, due the genetic heterogeneity, racial differences and environmental influences on disease aetiology. Utilization of murine models of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autoimmunity
• Share to Disease Models, Animal
• Share to Genetic Heterogeneity