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Article

Rare alleles within the CYP2E1 (MEOS system) could be associated with better short-term health outcome after acute methanol poisoning.

Basic & clinical pharmacology & toxicology - 1 Feb 2015

Hubacek Jaroslav A, Pelclova Daniela, Seidl Zdenek, Vaneckova Manuela, Klempir Jiri, Ruzicka Evzen, Ridzon Petr, Urban Pavel, Fenclova Zdenka, Petrik Vit, Diblik Pavel, Kuthan Pavel, Miovsky Michal, Janikova Barbara, Adamkova Vera, Zakharov Sergey

Abstract excerpt

Genetic polymorphisms influence the metabolism of ethanol and methanol, but the potential effects of genetic predisposition on the clinical course, outcome and short-term health sequelae of acute methanol poisoning are unknown. To evaluate the role of the MEOS system in methanol poisoning, we analysed the effect of three polymorphisms (RsaI - rs2031920; PstI - rs3813867; insertion/deletion I/D) within the CYP2E1...

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PMID: 25146350
DOI: 10.1111/bcpt.12310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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