Article
Pharmacogenetic profile of xenobiotic enzyme metabolism in survivors of the Spanish toxic oil syndrome.
Environmental health perspectives - 1 Apr 2001
Ladona M G, Izquierdo-Martinez M, Posada de la Paz M P, de la Torre R, Ampurdanés C, Segura J, Sanz E J
Abstract excerpt
In 1981, the Spanish toxic oil syndrome (TOS) affected more than 20,000 people, and over 300 deaths were registered. Assessment of genetic polymorphisms on xenobiotic metabolism would indicate the potential metabolic capacity of the victims at the time of the disaster. Thus, impaired metabolic pathways may have contributed to the clearance of the toxicant(s) leading to a low detoxification or accumulation of...
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