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Article

Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans.

Clinical genetics - 1 Nov 2018

Hubacek J A, Jirsa M, Bobak M, Pelclova D, Zakharov S

Abstract excerpt

As the susceptibility of humans to xenobiotics often depends on genetic factors, we assumed that ADH1B and ALDH2 genetic variants may affect susceptibility to the acute methanol exposure. To evaluate the role of genetic variants of enzymes involved in methanol catabolism in humans, we analysed ADH1B (rs1229984) and ALDH2 (rs441) polymorphisms in 50 adults who survived acute methanol poisoning, 246 individuals...

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Source

Identifiers

PMID: 29968299
DOI: 10.1111/cge.13411

Genes

ALDH2

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