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Article

Genetic polymorphism of metabolic enzymes modifies the risk of chronic solvent-induced encephalopathy.

Toxicology and industrial health - 1 Aug 2006

Kezic Sanja, Calkoen Florentine, Wenker Mira A M, Jacobs John J L, Verberk Maarten M

Abstract excerpt

In the present study, we investigate whether genetic polymorphism in enzymes involved in the metabolism of organic solvents influences susceptibility to chronic solvent encephalopathy (CSE), which is one of the major effects of long-term exposure to organic solvents. Polymorphisms in the genes encoding CYP1A1, CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1 enzymes were determined in a group of male CSE patients (N=97) and...

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Source

Identifiers

PMID: 17022435
DOI: 10.1177/0748233706070287

Genes

EPHX1
GSTP1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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