Article
Role for the obesity-related FTO gene in the cellular sensing of amino acids.
Proceedings of the National Academy of Sciences of the United States of America - 12 Feb 2013
Gulati Pawan, Cheung Man Ka, Antrobus Robin, Church Chris D, Harding Heather P, Tung Yi-Chun Loraine, Rimmington Debra, Ma Marcella, Ron David, Lehner Paul J, Ashcroft Frances M, Cox Roger D, Coll Anthony P, O'Rahilly Stephen, Yeo Giles S H
Abstract excerpt
SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in severe growth retardation, and mice globally overexpressing FTO are obese. The mechanisms through which FTO...
Topics
Join the communities discussing this publication.