Article
Inactivation of the Fto gene protects from obesity.
Nature - 16 Apr 2009
Fischer Julia, Koch Linda, Emmerling Christian, Vierkotten Jeanette, Peters Thomas, Brüning Jens C, Rüther Ulrich
Abstract excerpt
Several independent, genome-wide association studies have identified a strong correlation between body mass index and polymorphisms in the human FTO gene. Common variants in the first intron define a risk allele predisposing to obesity, with homozygotes for the risk allele weighing approximately 3 kilograms more than homozygotes for the low risk allele. Nevertheless, the functional role of FTO in energy...
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