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Article

FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver.

Cell communication and signaling : CCS - 10 Jan 2014

Bravard Amélie, Vial Guillaume, Chauvin Marie-Agnès, Rouillé Yves, Bailleul Bernard, Vidal Hubert, Rieusset Jennifer

Abstract excerpt

BACKGROUND: The fat mass and obesity associated (FTO) gene is related to obesity and type 2 diabetes, but its function is still largely unknown. A link between leptin receptor-signal transducers and activators of transcription 3 (LepR-STAT3) signalling pathway and FTO was recently suggested in the hypothalamus. Because of the presence of FTO in liver and the role of LepR-STAT3 in the control of hepatic...

Read the complete abstract on PubMed

Topics

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Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Glucose-6-Phosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria, Liver

Share to Oxo-Acid-Lyases

Share to Receptors, Leptin

Share to STAT3 Transcription Factor

Share to Suppressor of Cytokine Signaling 3 Protein

Share to Suppressor of Cytokine Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24410832
DOI: 10.1186/1478-811X-12-4
PMCID: PMC3896784

Genes

FTO
STAT3
SOCS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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