Article
Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma.
Acta neuropathologica - 1 Oct 2014
Sahm Felix, Reuss David, Koelsche Christian, Capper David, Schittenhelm Jens, Heim Stephanie, Jones David T W, Pfister Stefan M, Herold-Mende Christel, Wick Wolfgang, Mueller Wolf, Hartmann Christian, Paulus Werner, von Deimling Andreas
Abstract excerpt
Astrocytoma and oligodendroglioma are histologically and genetically well-defined entities. The majority of astrocytomas harbor concurrent TP53 and ATRX mutations, while most oligodendrogliomas carry the 1p/19q co-deletion. Both entities share high frequencies of IDH mutations. In contrast, oligoastrocytomas (OA) appear less clearly defined and, therefore, there is an ongoing debate whether these tumors indeed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.