Article
Genetically distinct astrocytic and oligodendroglial components in oligoastrocytomas.
Acta neuropathologica - 1 Feb 2007
Qu Mingqi, Olofsson Tommie, Sigurdardottir Sunna, You Chao, Kalimo Hannu, Nistér Monica, Smits Anja, Ren Zhi-Ping
Abstract excerpt
Oligoastrocytomas are glial tumours consisting of a mixture of neoplastic astrocytic and oligodendroglial cells. Genetic alterations of oligoastrocytomas include loss of heterozygosity of chromosomes 1p and/or 19q (LOH 1p/19q), typically occurring in oligodendrogliomas, and mutations of TP53, frequently occurring in astrocytomas. To investigate whether these neoplastic cell types in oligoastrocytomas have...
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