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Article

Comprehensive screening for mutations associated with colorectal cancer in unselected cases reveals penetrant and nonpenetrant mutations.

International journal of cancer - 15 Mar 2015

Kraus Cornelia, Rau Tilman T, Lux Philipp, Erlenbach-Wünsch Katharina, Löhr Sabine, Krumbiegel Mandy, Thiel Christian T, Stöhr Robert, Agaimy Abbas, Croner Roland S, Stürzl Michael, Hohenberger Werner, Hartmann Arndt, Reis André

Abstract excerpt

Germline mutation testing in patients with colorectal cancer (CRC) is offered only to a subset of patients with a clinical presentation or tumor histology suggestive of familial CRC syndromes, probably underestimating familial CRC predisposition. The aim of our study was to determine whether unbiased screening of newly diagnosed CRC cases with next generation sequencing (NGS) increases the overall detection rate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to MutL Protein Homolog 1

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Source

Identifiers

PMID: 25142776
DOI: 10.1002/ijc.29149

Genes

MLH1
MSH6
APC
BRAF
MLH3
MSH2
MSH3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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