Article
Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.
Gastroenterology - 1 Sept 2015
Yurgelun Matthew B, Allen Brian, Kaldate Rajesh R, Bowles Karla R, Judkins Thaddeus, Kaushik Praveen, Roa Benjamin B, Wenstrup Richard J, Hartman Anne-Renee, Syngal Sapna
Abstract excerpt
BACKGROUND & AIMS: Multigene panels are commercially available tools for hereditary cancer risk assessment that allow for next-generation sequencing of numerous genes in parallel. However, it is not clear if these panels offer advantages over traditional genetic testing. We investigated the number of cancer predisposition gene mutations identified by parallel sequencing in individuals with suspected Lynch...
Topics
- Adult
- Biomarkers, Tumor
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Mutational Analysis
- Female
- Gene Expression Profiling
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Testing