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Whole exome sequencing identifies MAP3K1, MSH2, and MLH1 as potential cancer-predisposing genes in familial early-onset colorectal cancer.

The Kaohsiung journal of medical sciences - 1 Sept 2023

Fatemi Nayeralsadat, Tu Siang-Jyun, Chung Chin-Chun, Moghadam Pardis Ketabi, Mojarad Ehsan Nazemalhosseini, Sadeghi Amir, Totonchi Mehdi, Aghdaei Hamid Asadzadeh, Chang Jan-Gowth

Abstract excerpt

The incidence of early-onset colorectal cancer (CRC), which affects people under 50, is increasing for unknown reasons. Additionally, no underlying genetic cause is found in 20%-30% of patients suspected of having familial CRC syndrome. Whole exome sequencing (WES) has generated evidence for new genes associated with CRC susceptibility, but many patients remain undiagnosed. This study applied WES in five...

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PMID: 37314251
DOI: 10.1002/kjm2.12715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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