Article
Using gene genealogies to detect rare variants associated with complex traits.
Human heredity - 1 Jan 2014
Burkett Kelly M, McNeney Brad, Graham Jinko, Greenwood Celia M T
Abstract excerpt
BACKGROUND AND OBJECTIVE: Standard population genetic theory says that deleterious genetic variants are likely rare and fairly recently introduced. However, can this expectation lead to more powerful tests of association between diseases and rare genetic variation? The gene genealogy describes the relationships between haplotypes sampled from the general population. Although ancestral tree-based methods, inspired...
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