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Article

Ancestral haplotype reconstruction in endogamous populations using identity-by-descent.

PLoS computational biology - 1 Feb 2021

Finke Kelly, Kourakos Michael, Brown Gabriela, Dang Huyen Trang, Tan Shi Jie Samuel, Simons Yuval B, Ramdas Shweta, Schäffer Alejandro A, Kember Rachel L, Bućan Maja, Mathieson Sara

Abstract excerpt

In this work we develop a novel algorithm for reconstructing the genomes of ancestral individuals, given genotype or sequence data from contemporary individuals and an extended pedigree of family relationships. A pedigree with complete genomes for every individual enables the study of allele frequency dynamics and haplotype diversity across generations, including deviations from neutrality such as transmission...

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Identifiers

PMID: 33635861
DOI: 10.1371/journal.pcbi.1008638
PMCID: PMC7946327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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