Article
Using Gene Genealogies to Localize Rare Variants Associated with Complex Traits in Diploid Populations.
Human heredity - 1 Jan 2018
Karunarathna Charith B, Graham Jinko
Abstract excerpt
BACKGROUND AND AIMS: Many methods can detect trait association with causal variants in candidate genomic regions; however, a comparison of their ability to localize causal variants is lacking. We extend a previous study of the detection abilities of these methods to a comparison of their localization abilities. METHODS: Through coalescent simulation, we compare several popular association methods. Cases and...
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