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Article

Methylome analysis identifies a Wilms tumor epigenetic biomarker detectable in blood

18 Aug 2014

Abstract excerpt

BACKGROUND: Wilms tumor is the most common pediatric renal malignancy and there is a clinical need for a molecular biomarker to assess treatment response and predict relapse. The known mutated genes in this tumor type show low mutation frequencies, whereas aberrant methylation at 11p15 is by far the most common aberration. We therefore analyzed the epigenome, rather than the genome, to identify ubiquitous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25134821
DOI: 10.1186/s13059-014-0434-y

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